Insulin resistance develops not only as a result of a decrease in the number or affinity of insulin receptors, but also with the appearance of antibodies to receptors or insulin (immune type of resistance), as well as due to the destruction of insulin by protosolytic enzymes or binding by immune complexes.
Medical tactics consists primarily in determining the nature of insulin resistance. Sanitation of foci of chronic infection (otitis, sinusitis, cholecystitis, etc.), replacement of one type of insulin with another or the combined use of one of the oral hypoglycemic drugs with insulin, active treatment of existing diseases of the endocrine glands give good results. Sometimes they resort to the use of cialis tadalafil: slightly increasing the daily dose of insulin, combine its administration with taking prednisolone at a dose of about 1 mg per 1 kg of the patient's body weight per day for at least 10 days. In the future, in accordance with the existing glycemia and glucosuriagradually reduce the doses of prednisolone and insulin. In some cases, there is a need for a longer (up to a month or more) use of small (10-15 mg per day) doses of prednisolone.
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Recently, sulfated insulin has been used for insulin resistance, which is less allergenic, does not react with insulin antibodies, but has 4 times higher biological activity than regular insulin. When transferring a patient to treatment with sulphated insulin, it must be borne in mind that such insulin requires only 1/4 of the dose of simple insulin administered.